Cystic Fibrosis (CF)

Disease #1

Cystic fibrosis is genetic disorder, which means that the inheritance of condition is inherited either from your parents or runs in the families. It is the most common fatal genetic disease in the US today.

It causes the body to produce a thick, sticky mucus that clogs the lungs, leading to infection, and blocks the pancreas, stopping digestive enzymes from reaching the intestines where they are required to digest food.

Inheritance:
Since Cystic Fibrosis is an autosomal recessive,it means that the disorder is inherited from both your parents, who are both usually symptom free carriers.

Symptoms
1) ductal systems and other passageways become clogged w/ unusually thick secretions.

2) Salty sweats

3) Unable to digest food

4)Taking hard breathes, having difficulty breathing.

Detection:
The standard diagnostic test for CF is the quantitative sweat chloride test, or "sweat test," which measures the amount of salt in the sweat.

For newborns, an immunoreactive trypsinogen test (IRT) may be used instead.

Other tools for diagnosis include chest X-rays, which may reveal characteristic respiratory complications, and lung function tests, which may indicate abnormal airway function.





Treatment:
1) Gene Therapy

2) Direct protein (functional CFTR) insertion into epithelium cells (by inhalation)

3) Traditional ways, CPT (Chest physical therapy).